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ZADAXIN
(thymosin alpha 1)
ZADAXIN
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Table of Contents
List of Tables and Figures
List of Abbreviations
Introduction
Chemical Properties of Zadaxin (thymalfasin)
Mechanism of Action of Zadaxin
Use of Zadaxin in Disease States
Animal Models
Woodchuck Hepatitis
Other Animal Models of Infection
Animal Models of Cancer
Hepatitis B
Hepatitis B Treatment Options
Zadaxin Monotherapy in Hepatitis B
Zadaxin Plus IFN
α
Combination Therapy for Chronic Hepatitis B
Zadaxin Plus Nucleoside Analogues Combination Treatment for Chronic Hepatitis B
Key Takeaways
Hepatitis C
Clinical Trials
Zadaxin Plus IFN
α
Combination Therapy for Chronic Hepatitis C
US hepatitis C trial
Italian Hepatitis C trial and Thailand Hepatitis C trial, Interim Results
Summary and Key Takeaways
Human Immunodeficiency Virus
Vaccine Adjuvant in Immunocompromised Patients
Introduction
Cornell Medical Center (Ithaca, New York) and University of Wisconsin trials
George Washington University trial
Hemodialysis Patients
Key Takeaways
Cancer
Introduction
Hepatocellular Carcinoma
NonSmall-Cell Lung Cancer
Malignant Melanoma
Key Takeaways
Toxicity and Safety
Toxicity in Animals and in Vitro
Safety in Humans
Human Pharmacokinetics
References
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