SciClone Pharmaceuticals International

蓽 � 穗
玸 � 虷 � � 專寠 � � � 砉磷

毬刳鷤貹渠蝕

彲比鷤

�� 夕

毬刳鷤貹渠蝕

劍拇羢テ洪誥

� 懓 1 毬渠 � 瓴頻拘 Ы 菞嫸鑨蓶柆渠 � 裯佪劍拇羢テ洪誥磷 � 柜玾 223 匎鷸竿遞 3 匎毐累遞矯控 � 臸夷狊遞蔋 � 斵 � 遞 � 車夷狊聏肉蔕袷舞磷蒐狂 � 懓 1瞭拴周 2 秖瞭柜 6 匎 � 瞭 § � � 毐涗 12 匎 � 縲派臸 � 繃磷

� 懓 1 瓴頻裯佪劍拇羢テ洪誥遞佪 �

蔋 � � 毗群忟	鷸胾僥裯佪蚐	12 匎 � � ︼ � 遞玾 � 茙 ^*
� � 蔋 � 2 怎 [1,5]	12 竿縲 � 懓 1 穗 1.6mg, � 臸蒐狂瞭拴周 2 秖 , 6 匎 � 繃 8 竿縲洄飾莊繃	(83%) 縲 � 懓蚐繃 (25%) 縲洄飾莊蚐繃
� � 蔋 � 3 怎 [2,5]	50 竿縲 � 懓 1穗 1.6mg, � 臸蒐狂瞭拴周 2 秖瞭 6 匎 � 繃 49 竿縲洄飾莊繃	(24%) 縲� 懓蚐 ) (12%) 縲洄飾莊蚐繃
掌娠蔋 � 3 怎 [3,4,5]	51 竿縲 � 懓 1穗 1.6mg, � 臸蒐狂瞭拴周 2 秖瞭 6 匎 � 繃 53 竿縲無裯佪繃	(37%) 縲 � 懓蚐繃 (25%) 縲無裯佪蚐 )
肉蔕袷舞 [5]	113 竿縲 � 懓 1穗 1.6mg , � 臸蒐狂瞭罦周 2 秖瞭 6 匎 � 繃 110 縲洄飾莊拘無裯佪繃	(36%) 縲 � 懓蚐繃 (19%) 縲洄飾莊拘無裯佪繃

^* 玾 � 茙涍定璤癒 12 匎 � � � 粈 HBV DNA 貹 HBeAg 切癒珣拇遞鷸竿遞盻袷茙磷

涂毖 � 毗 � � � 帴嵐柪 § � 裯佪 � 12 匎 � 拘 � 遛 � 汐茛湊延濫遞裯佪 � 刳磷柪 � 帴嵐遞裯佪詗瞭嫟幾荁罦弶拇名弶 � 剞 2 釔遞 ALT 蜴 ⊥ 磷 � 幾荁缹摩弶拇 ALT 蜴 ⊥ � 瞭 ﹝ そ玾洪！ � 遞鷤鄞和 � 彼瞭于め刳 �~ �� 科渠 � 帴嵐磷

柺 � 虷疿

劍拇詒テ洪誥

� 帴嵐毬渠 � Ы 菞嫸鑨蓶柆渠 � 裯佪劍拇詒テ洪誥磷 � 2 匎毐累遞矯 � 搿遞蔋 � 斵 � 寒貹 1 匎 � 扉 � 搿遞蔋 � 斵 � 夷狊聏肉蔕袷舞磷蔕柜玾 121 匎蓶柆科渠 � 帴嵐貹菞嫸鑨拘瓴頻科渠菞嫸鑨遞鷸竿磷斵 � 詗瞭蒐狂 � 懓 1 � � 罦周 2 秖瞭 6 � 12 匎 � 磯蒐狂菞嫸鑨毖帴罦周 3 秖瞭 6 � 12 匎 � 磷孔洉裯佪 � � 寒貹孔洉裯佪 � 6 匎 � 夷狊聏︼ � � � 磷縲派臸 � 繃

� 懓 1 蓶柆菞嫸鑨裯佪劍拇詒テ洪誥菑佪 �

蔋 � � 毗群忟	裯佪蚐鷸竿僥 ^*	裯佪衃玾 � 茙 ^**	� �� 玾 � 茙 ^***
� � 蔋 � 3 怎 [6,9]	35 竿科渠 � 懓 1 + 菞嫸鑨縲 � 懓 1穗 � 臸蒐狂瞭罦周 2 秖瞭 6 匎 � 磯菞嫸鑨穗 3MU瞭罦周 3 秖瞭 6 匎 � ) 37 竿科渠菞嫸鑨 ( 菞嫸鑨 3MU瞭罦周 3 秖瞭 6 匎 � ) 37 竿縲洄飾莊繃	ALT 貵刳穗 � 懓 1 + 菞嫸鑨礁 37.1% 菞嫸鑨礁 16.2% 洄飾莊礁 2.7% 鷸瀑貵刳穗 � 懓 1 + 菞嫸鑨礁 37.1% 菞嫸鑨礁 18.9% 洄飾莊礁 2.7%	ALT 貵刳穗 � 懓 1 + 菞嫸鑨礁 19.2% 菞嫸鑨礁 9.4%
嘁菫十蔋 � 2 怎 [7,9]	15 竿縲 � 懓 1穗 1.0mg瞭拴 � � 臸蒐狂瞭柜 4 � , 然 � 枻罦周 2 秖瞭 51 周 + 柪 � 4 � 蒐狂菞嫸鑨穗 3MU, 菑 � 罦周 3 秖瞭 51 周 )	鷸瀑貵刳穗 � 懓 1 + 菞嫸鑨礁 73.3%	鷸瀑貵刳穗 � 懓 1 + 菞嫸鑨礁 40.0%
嘁菫十蔋 � 2 怎 [8,9]	17 竿縲 � 懓 1穗 1.6mg瞭罦周 2 秖瞭 6 匎 � + 菞嫸鑨穗 3MU瞭罦周 3 秖瞭 6 匎 � 繃 17 竿科渠菞嫸鑨	ALT 貵刳穗 � 懓 1 + 菞嫸鑨礁 70.6% 菞嫸鑨礁 35.3%	ALT 貵刳穗 � 懓 1 + 菞嫸鑨礁 29.4% 菞嫸鑨礁 17.6%
� 車肉蔕 [9]	67 竿縲 � 懓 1穗 1.6mg瞭罦周 2 秖瞭 6 � 12 匎 � + 菞嫸鑨穗 3MU瞭罦周 3 秖瞭 6 � 12 匎 � ) 54 竿科渠菞嫸鑨	ALT 貵刳穗 � 懓 1 + 菞嫸鑨礁 44.7% 菞嫸鑨礁 22.2% ⁺	ALT 貵刳穗 � 懓 1 + 菞嫸鑨礁 22.4% 菞嫸鑨礁 9.3% ⁺⁺

^* 蔋 � � 毗裯佪菑袷舞
^** ALT 玾 � 茙涍定璤癒柪裯佪衃 ALT 冒常鷸竿遞盻袷茙磷鷸瀑玾 � 茙涍定璤癒 HCV RNA 冒常鷸竿遞盻袷茙磷
^*** ALT 玾 � 茙涍定璤癒 6 匎 � ︼ � 衃 ALT冒常鷸竿遞盻袷茙磷鷸瀑玾 � 茙涍定璤癒 6 匎 � ︼ � 衃 HCV RNA 冒常鷸竿遞盻袷茙磷� � 蔋 � 3 怎詗 � �� 佪 � 迵茀詗弼鮮裯佪聏 6 匎 � 遞鷸竿寒貹嬅嬅 �� 柜裯佪聏 12 匎 � 遞鷸竿磷
+P=0.0096
++P=0.10

� � 蔋 � � 毗裯佪蚐夷狊肉蔕袷舞發荁瞭裯佪 6 � 12 匎 � � 瞭 ALT 冒常茙柪蓶柆裯佪蚐癒 22.4% 瞭柪瓴頻科渠菞嫸鑨蚐癒 9.3% 磷

柺 � 虷疿

鎮胅 � 莊

� � 八鎮嫮西遞鷸胾瞭 � 懓 1 惺一癒獵嘂鎮胅接摩遞八鎮 � 莊縲八鎮貵刳鈷強莊繃磷 � � 浂 �� 菫魁瞭 � 懓 1 惺一癒獵嘂鎮胅遞八鎮 � 莊磷 � � 姚接摩鎮胅眈晶 � 茛湊玲＞ � � 德ホ遞 � 笉烚舞鷸胾瞭 � 懓 1惺一癒接摩獵嘂鎮胅貹羢洪鎮胅遞八鎮 � 莊縲派臸 � 繃磷

� 懓 1遞八鎮 � 莊 � 刳

� 毗 � �m	裯佪蚐鷸竿僥 ^*	貵刳茙 ^**
� � 蔋 � 2 怎 � 浂胾獵嘂鎮胅 [10]	9 胾科渠 � 懓 1縲 900 mug/m² ^*** 瞭 � 蒐罦周 2 秖柜 5 周繃 6 胾一 � 扉 � 搿	� 懓 1 蚐礁 67% � 扉 � 搿蚐礁 10%
� � 蔋 � 3 怎 � 浂胾獵嘂鎮胅 [11]	45 胾科渠 � 懓 1縲 900 mug/m² ^*** 瞭罦周 2 秖柜 4 周繃 40 胾科渠洄飾莊	� 懓 1礁 67% 洄飾莊礁 53%
� � 蔋 � 2 怎 � 浂胾獵嘂鎮胅 [12]	110 胾科渠 � 懓 1縲 900mug/m² ^* 瞭罦周 2秖柜 2周繃 111胾科渠 � 懓 1縲 900 mug/m² ^* 瞭罦周 2 秖柜 4 周繃 109 胾科渠洄飾莊	科渠 8 秖蚐 � 科渠 4 秖蚐寒貹洄飾莊蚐貵刳茙迵茀 � 嘁璤舄 � 街 ◆
� � 蔋 � 3 怎 � 笉烚舞魁獵嘂鎮胅 [13]	48 胾科渠 � 懓 1縲 900 mug/m² ^*** 瞭罦周 2 秖柜 4 周繃 49 胾科渠洄飾莊	4 周 � 礁 � 懓 1 礁 71% 洄飾莊礁 43% 8 周 � 礁 � 懓 1 礁 65% 洄飾莊礁 24%
� � 蔋 � 3 怎 � 笉烚舞魁羢洪鎮胅 [14,15]	11 胾科渠 � 懓 1縲接摩 � 瞭拴 � 900 mug/m² ^*** 柜 3 � 瞭接街罦周 2 秖柜 2 周繃 12縲洄飾莊 )	3 匎 � 礁 � 懓 1礁 64% 洄飾莊礁 17% 6 匎 � 礁 � 懓 1礁 45% 洄飾莊礁 17% 9, 12 匎 � 礁 � 懓 1礁 45% 洄飾莊礁 0%
嘁菫十蔋 � 3 怎 � 笉烚舞魁羢洪鎮胅 [16]	接摩 � 渠 � 懓 1穗 900 mug/m² ^*** 瞭罦周 2 秖柜 3 周繃洄飾莊	12 匎 � � � 懓 1 蚐 � � 德ホ ◆ 4 釔

^* 裯佪蚐 ﹝ 接摩鎮胅揍瞭踣科渠 � 懓

1 磷洄飾莊蚐拘 � 搿蚐戟接摩鎮胅砐菇科渠 � 懓

磷
^** 貵刳茙涍定璤癒拴匎 � 毗詗瞭 � 斵魁茛湊玲＞ ◆ � � � 棣遞盻袷茙磷
^*** 900mug/m² 菫 � 癒 1.6 mg磷

柺 � 虷疿

毬 刳 鷤 貹 渠 蝕

劍 拇 羢 テ 洪 誥

� 懓 1 瓴 頻 裯 佪 劍 拇 羢 テ 洪 誥 遞 佪 �

劍 拇 詒 テ 洪 誥

� 懓 1 蓶 柆 菞 嫸 鑨 裯 佪 劍 拇 詒 テ 洪 誥 菑 佪 �

鎮 胅 � 莊

� 懓 1遞 八 鎮 � 莊 � 刳

毬刳鷤貹渠蝕

劍拇羢テ洪誥

� 懓 1 瓴頻裯佪劍拇羢テ洪誥遞佪 �

劍拇詒テ洪誥

� 懓 1 蓶柆菞嫸鑨裯佪劍拇詒テ洪誥菑佪 �

鎮胅 � 莊

� 懓 1遞八鎮 � 莊 � 刳